Discover the natural solution to cryopreservation

Osmolyte-based Cryopreservation Technology

Beaker

SAFE AND NATURALLY-OCCURING

Osmolytes are safe naturally-occurring sugars, sugar alcohols and amino acids

ORGANIC COMPOUNDS

Organic compounds that work together to stabilize and protect the integrity of cells during cryopreservation

OPTIMIZED FOR EACH CELL

Proprietary algorithm optimizes cryoprotectant formulation to support different cell types

DMSO damages cells, causes high cell losses during manufacturing, and is harmful to patients.

  • Patients infused with cell therapeutics that contain DMSO experience adverse reactions from nausea to cardiac toxicity.
  • Cell exposure to DMSO for extended periods of time during manufacturing results in significant cell loss.
  • Immune cell therapeutic efficacy is reduced post thawing.
  • Kollerup Madsen B et al. Adverse reactions of dimethyl sulfoxide in humans: a systematic review. F1000Res. 2018 Nov 5;7:1746.
  • Maral S et al. Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. Cell Tissue Bank. 2018 Dec;19(4):831-832.
  • Heneghan C et al. Safety of hematopoietic cell infusion in children with malignant and non-malignant diseases. Pediatr Transplant. 2017 Nov;21(7).
  • Zenhäusern R et al. Fatal cardiac arrhythmia after infusion of dimethyl sulfoxide-cryopreserved hematopoietic stem cells in a patient with severe primary cardiac amyloidosis and end-stage renal failure. Ann Hematol. 2000 Sep;79(9):523-6.
  • Li R et al. Preservation of cell-based immunotherapies for clinical trials. Cytotherapy. 2019 Sep;21(9):943-957.
  • Lapteva N et al. Clinical grade purification and expansion of natural killer cells. Crit Rev Oncog. 2014;19(1-2):121-32.
Liquid nitrogen cryogenic tank at life sciences laboratory

How do trees survive Minnesota winters?

The answer to that question helped us develop a novel strategy of preserving cells.

DISRUPTIVE CRYOPRESERVATION TECHNOLOGY

After 30 years of sub-standard one-size-fits-all cryopreservation technology, the industry is about to change.

Evia Bio’s DMSO-free cryopreservation technology enables the entire cell therapy supply chain.

Patient Safety Icon

Patient Safety

Generally Regarded As Safe, GRAS components

Yield Icon

Product Yield

>85% recovery and viability with iPSCs, MSCs, sensory neurons, and T-cells

Yield Icon

Product Efficacy

Superior function, >99% signaling with iPSC derived sensory neurons

Supply Chain icon

Supply Chain

No washing required, time and process flexibility and efficiency in manufacturing

PUBLICATIONS

Stem Cells
Immunotherapies
  1. Li, R et al. Preservation of cell-based immunotherapies for clinical trials. Cytotherapy. 2019; 21. 943-957.
  2. Yu, G and Hubel, A. The Role of Preservation in the Variability of Regenerative Medicine Products. Regenerative Engineering and Translational Medicine. 2019. 1-9

Get the latest cryopreservation news, CryoChats™ info, and all the updates.

Evia Bio

Office

2001 6th St SE, Room 2-434
Minneapolis, MN 55455

© 2023 Evia Bio • Privacy Policy