Evia Bio’s naturally-occurring osmolytes maintain cellular viability and function during cryopreservation and streamline the cell therapy industry supply chain.

THE EVIA BIO CRYOPRESERVATION ADVANTAGE

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Patented Formulation

Osmolytes: naturally-occurring sugars, sugar alcohols and amino acids that protect cells during cryopreservation process

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Improved Results

Superior cell viability and functionality, no patient safety concerns, and efficient manufacturing process

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Low Regulatory Hurdle

Generally Regarded As Safe (GRAS) components

Proprietary Algorithm

Proprietary Algorithm

Cryopreservation formulation optimization using iterative algorithm

Cell Therapy Solutions

Evia Bio’s DMSO-free cryopreservation solutions are tailored specifically for each cell type through our proprietary algorithm that optimizes the formulation based on target performance assays. Engage with us to replace your DMSO-based cryopreservation with an all-natural cryoprotectant that keeps cells happy and patients safe.
Cell Viability and Recovery

Cell Viability and Recovery

>90% viability and recovery with all the top Cell & Gene Therapy cell types: T-cells, NKs, iPSCs, and MSCs

Reattachment and Expansion

Reattachment and Expansion

Superior iPSC reattachment compared to DMSO and identical post-thaw growth rate as non-frozen iPSCs

Product Efficacy

Product Efficacy

>99% calcium signaling of iPSC derived sensory neurons and maintained self-renewal and pluripotency of iPSCs and differentiation capacity of MSCs

SUPERIOR PERFORMANCE

We have demonstrated Evia Bio’s cryoprotectant superior performance over DMSO-based and DMSO-free products in multiple studies – internal R&D projects, confidential customer projects, and peer-reviewed publications – with a broad range of cells typically used in cell & gene therapies: T Cells, T Cells, Natural Killer (NK) Cells, Induced Pluripotent Stem Cells (iPSCs), Mesenchymal Stem Cells (MSCs), and Apheresis products.

Supply Chain Management

After 30 years of sub-standard one size fits all cryopreservation technology, the industry is about to change.

Evia Bio’s DMSO-free cryopreservation technology enables the entire cell therapy supply chain.

Time Sensitivity with DMSO and Loss of Cell Viability
  • Significant cell viability loss with DMSO within 30 min pre- and post-freezing
  • Strict processing times needed with DMSO that complicate solution introduction
DMSO Washing During Manufacturing
  • 10-20 % cell loss with each DMSO washing step
  • Multiple freezing/thawing and washing steps
DMSO at Point of Care and Infusion
  • Toxicity and patient infusion adverse effects if DMSO is not washed at the point of care
Evia Bio Solutions for Efficient and Flexible Manufacturing Processes
  • Robust cell performance in Evia Bio’s cryoprotectant even with variable processing times
  • Safe components for patients, no washing required
  • Cryopreservation formulation optimization using iterative algorithm

Get the latest cryopreservation news, CryoChats™ info, and all the updates.

Evia Bio

Office

2001 6th St SE, Room 2-434
Minneapolis, MN 55455

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