Ditch DMSO
Do Better
Discover the natural solution to cryopreservation with Osmolyte-based technology
Safe & Naturally
Occuring
Osmolytes are safe naturally-occurring sugars, sugar alcohols and amino acids
Organic
Compounds
Organic compounds that
work together to stabilize & protect the integrity of cells during cryopreservation
Optimized for
Each Cell
Proprietary algorithm optimizes cryoprotectant formulation to support different cell types
DMSO damages cells, causes high cell losses during manufacturing, and is harmful to patients.
Patients infused with cell therapeutics that contain DMSO experience adverse reactions from nausea to cardiac toxicity.
Cell exposure to DMSO for extended periods of time during manufacturing results in significant cell loss.
Immune cell therapeutic efficacy is reduced post thawing.
Maral S et al. Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. Cell Tissue Bank. 2018 Dec;19(4):831-832.
Heneghan C et al. Safety of hematopoietic cell infusion in children with malignant and non-malignant diseases. Pediatr Transplant. 2017 Nov;21(7).
Zenhäusern R et al. Fatal cardiac arrhythmia after infusion of dimethyl sulfoxide-cryopreserved hematopoietic stem cells in a patient with severe primary cardiac amyloidosis and end-stage renal failure. Ann Hematol. 2000 Sep;79(9):523-6.
Li R et al. Preservation of cell-based immunotherapies for clinical trials. Cytotherapy. 2019 Sep;21(9):943-957.
Lapteva N et al. Clinical grade purification and expansion of natural killer cells. Crit Rev Oncog. 2014;19(1-2):121-32.
The answer to that question helped us develop a novel strategy of preserving cells.
Disruptive Cryopreservation Technology
After 30 years of sub-standard one-size-fits-all cryopreservation technology, the industry is about to change. Evia Bio’s DMSO-free cryopreservation technology enables the entire cell therapy supply chain.
Patient Safety
Generally Regarded
As Safe, GRAS components
Product Yield
>85% recovery and viability with iPSCs,
MSCs, sensory neurons, and T-cells
Product Efficacy
with iPSC derived sensory neurons
Supply Chain
flexibility and efficiency in manufacturing
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