Ditch DMSO

Do Better

Discover the natural solution to cryopreservation with Osmolyte-based technology

Safe & Naturally
Occuring

Osmolytes are safe naturally-occurring sugars, sugar alcohols and amino acids

Organic
Compounds

Organic compounds that
work together to stabilize & protect the integrity of cells during cryopreservation

Optimized for
Each Cell

Proprietary algorithm optimizes cryoprotectant formulation to support different cell types

DMSO damages cells, causes high cell losses during manufacturing, and is harmful to patients.

Check-Shield--Streamline-Ultimate

Patients infused with cell therapeutics that contain DMSO experience adverse reactions from nausea to cardiac toxicity.

Check-Shield--Streamline-Ultimate

Cell exposure to DMSO for extended periods of time during manufacturing results in significant cell loss.

Check-Shield--Streamline-Ultimate

Immune cell therapeutic efficacy is reduced post thawing.

Kollerup Madsen B et al. Adverse reactions of dimethyl sulfoxide in humans: a systematic review. F1000Res. 2018 Nov 5;7:1746.
Maral S et al. Dimethyl Sulfoxide-Induced Tonic-Clonic Seizure and Cardiac Arrest During Infusion of Autologous Peripheral Blood Stem Cells. Cell Tissue Bank. 2018 Dec;19(4):831-832.
Heneghan C et al. Safety of hematopoietic cell infusion in children with malignant and non-malignant diseases. Pediatr Transplant. 2017 Nov;21(7).
Zenhäusern R et al. Fatal cardiac arrhythmia after infusion of dimethyl sulfoxide-cryopreserved hematopoietic stem cells in a patient with severe primary cardiac amyloidosis and end-stage renal failure. Ann Hematol. 2000 Sep;79(9):523-6.
Li R et al. Preservation of cell-based immunotherapies for clinical trials. Cytotherapy. 2019 Sep;21(9):943-957.
Lapteva N et al. Clinical grade purification and expansion of natural killer cells. Crit Rev Oncog. 2014;19(1-2):121-32.
Quote Graphic

    How do trees survive Minnesota winters?
    The answer to that question helped us develop a novel strategy of preserving cells. Quote Graphic
Allison Hubel

Disruptive Cryopreservation Technology

After 30 years of sub-standard one-size-fits-all cryopreservation technology, the industry is about to change. Evia Bio’s DMSO-free cryopreservation technology enables the entire cell therapy supply chain.

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Patient Safety

Generally Regarded
As Safe, GRAS components

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Product Yield

>85% recovery and viability with iPSCs,
MSCs, sensory neurons, and T-cells

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Product Efficacy

Superior function, >99% signaling
with iPSC derived sensory neurons
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Supply Chain

No washing required, time and process
flexibility and efficiency in manufacturing
PUBLICATIONS
Overview
  1. Hubel, A. Impact of freeze-thaw processes on the quality of cells. BioInsights. 12, 2017. 807-813.
Stem Cells
Immunotherapies
  1. Li, R et al. Preservation of cell-based immunotherapies for clinical trials. Cytotherapy. 2019; 21. 943-957.
  2. Yu, G and Hubel, A. The Role of Preservation in the Variability of Regenerative Medicine Products. Regenerative Engineering and Translational Medicine. 2019. 1-9

OFFICE

2001 6th St SE, Room 2-434
Minneapolis, MN 55455

info@eviabio.com

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